The exchange of the discriminator base A73 for G is alone sufficient to convert human tRNA(Leu) into a serine-acceptor in vitro.

類似資料

• The discriminator bases G73 in human tRNA(Ser) and A73 in tRNA(Leu) have significantly different roles in the recognition of aminoacyl-tRNA synthetases.
  著者:: Breitschopf, K, 等
  出版事項: (1996)
• Identity elements of human tRNA(Leu): structural requirements for converting human tRNA(Ser) into a leucine acceptor in vitro.
  著者:: Breitschopf, K, 等
  出版事項: (1995)
• Structural studies on tRNA acceptor stem microhelices: exchange of the discriminator base A73 for G in human tRNALeu switches the acceptor specificity from leucine to serine possibly by decreasing the stability of the terminal G1-C72 base pair.
  著者:: Metzger, A U, 等
  出版事項: (1997)
• Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.
  著者:: Normanly, J, 等
  出版事項: (1992)
• NMR analysis of tRNA acceptor stem microhelices: discriminator base change affects tRNA conformation at the 3' end.
  著者:: Puglisi, E V, 等
  出版事項: (1994)