Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification.

The nucleolar protein fibrillarin (encoded by the NOP1 gene in yeast), is required for many post-transcriptional steps in yeast ribosome synthesis. A screen for mutations showing synthetic lethality with a temperature sensitive nop1-5 allele led to the identification of the NOP77 gene. NOP77 is esse...

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Publicado en:	EMBO J
Autores principales:	Bergès, T, Petfalski, E, Tollervey, D, Hurt, E C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8039506/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06612.x
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