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Atorvastatin Inhibits Hypercholesterolemia-Induced Calcification in the Aortic Valves via the Lrp5 Receptor Pathway

BACKGROUND: Calcific aortic valve disease is the most common indication for surgical valve replacement in the United States. The cellular mechanisms of valve calcification are not well understood. We have previously shown that cellular proliferation and osteoblastogenesis are important in the develo...

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Bibliografske podrobnosti
Main Authors: Rajamannan, Nalini M., Subramaniam, Malayannan, Caira, Frank, Stock, Stuart R., Spelsberg, Thomas C.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951868/
https://ncbi.nlm.nih.gov/pubmed/16159822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.CIRCULATIONAHA.104.524306
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