An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis.

We have previously shown that a protein derived from the p7 nucleocapsid (NC) protein of HIV type-1 increases kcat/Km and kcat for cleavage of a cognate substrate by a hammerhead ribozyme. Here we show directly that the increase in kcat/Km arises from catalysis of the annealing of the RNA substrate...

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Библиографические подробности

Опубликовано в::	EMBO J
Главные авторы:	Herschlag, D, Khosla, M, Tsuchihashi, Z, Karpel, R L
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 1994
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8026476/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06586.x
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