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Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly-ADP-ribosylation
Dynamically controlled post-translational modifications of nucleosomal histones alter chromatin condensation to regulate transcriptional activation. We report that a nuclear tandem kinase, JIL-1, controls gene expression by activating Poly(ADP-ribose) Polymerase 1 (PARP-1). JIL-1 phosphorylates the...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3951681/ https://ncbi.nlm.nih.gov/pubmed/24508391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.005 |
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