Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys

Several classes of drugs bind to the dopamine transporter (DAT) with high affinity, but some are weaker positive reinforcers than cocaine, suggesting that affinity for and occupancy of the DAT is not the only determinant of a drug’s reinforcing effectiveness. Other factors such as the rate of onset...

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Hauptverfasser: Kimmel, Heather L., Nye, Jonathon A., Voll, Ronald, Stehouwer, Jeffrey, Goodman, Mark M., Votaw, John R., Carroll, F. I., Howell, Leonard L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951213/
https://ncbi.nlm.nih.gov/pubmed/22237864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.21536
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