UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

UHRF1 is an essential regulator of DNA methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, cultured cells and human tumors to demonstrate that UHRF1 is an oncogene. UHRF1 overexpression in zebrafish hepatocytes destabilizes and delocalizes DNMT1, causes DNA hypom...

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Hlavní autoři: Mudbhary, Raksha, Hoshida, Yujin, Chernyavskaya, Yelena, Jacob, Vinitha, Villanueva, Augusto, Fiel, M. Isabel, Chen, Xintong, Kojima, Kensuke, Thung, Swan, Bronson, Roderick T., Lachenmayer, Anja, Revill, Kate, Alsinet, Clara, Sachidanandam, Ravi, Desai, Anal, SenBanerjee, Sucharita, Ukomadu, Chinweike, Llovet, Josep M., Sadler, Kirsten C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951208/
https://ncbi.nlm.nih.gov/pubmed/24486181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.003
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