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UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis
Ubiquitin-like protein, containing PHD and RING finger domains-1 (UHRF1) is required for cell cycle progression and epigenetic regulation. In this study, we show that depleting cancer cells of UHRF1 causes activation of the DNA damage response pathway, cell cycle arrest in G2/M and apoptosis depende...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3291200/ https://ncbi.nlm.nih.gov/pubmed/21214517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100840 |
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