Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-Thrombospondin-1 axis

Lung stem cells are instructed to produce lineage-specific progeny through unknown factors in their microenvironment. We used clonal three-dimensional (3D) co-cultures of endothelial cells and distal lung stem cells, bronchioalveolar stem cells (BASCs), to probe the instructive mechanisms. Single BA...

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Main Authors: Lee, Joo-Hyeon, Bhang, Dong Ha, Beede, Alexander, Huang, Tian Lian, Stripp, Barry R., Bloch, Kenneth D., Wagers, Amy J., Tseng, Yu-Hua, Ryeom, Sandra, Kim, Carla F.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951122/
https://ncbi.nlm.nih.gov/pubmed/24485453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.12.039
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