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Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization

Microneedle vaccines mimic several aspects of cutaneous pathogen invasion by targeting antigen to skin-resident dendritic cells and triggering local inflammatory responses in the skin, which are correlated with enhanced immune responses. Here we tested whether control over vaccine delivery kinetics...

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Bibliografiske detaljer
Main Authors: DeMuth, Peter C., Min, Younjin, Irvine, Darrell J., Hammond, Paula T.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950936/
https://ncbi.nlm.nih.gov/pubmed/23847143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201300139
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