Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening.

The stability of transferrin receptor (TfR) mRNA is regulated by iron availability. When a human plasma-cytoma cell line (ARH-77) is treated with an iron source (hemin), the TfR mRNA is destabilized and a shorter TfR RNA appears. A similar phenomenon is also observed in mouse fibroblasts expressing...

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Publié dans:	EMBO J
Auteurs principaux:	Binder, R, Horowitz, J A, Basilion, J P, Koeller, D M, Klausner, R D, Harford, J B
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395039/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7909515/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06466.x
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