ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

Rescue of the p53 tumor suppressor is an attractive cancer therapy approach. However, pharmacologically activated p53 can induce diverse responses ranging from cell death to growth arrest and DNA repair, which limits the efficient application of p53-reactivating drugs in clinic. Elucidation of the m...

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Bibliografske podrobnosti
Main Authors: Shi, Y, Nikulenkov, F, Zawacka-Pankau, J, Li, H, Gabdoulline, R, Xu, J, Eriksson, S, Hedström, E, Issaeva, N, Kel, A, Arnér, E S J, Selivanova, G
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950324/
https://ncbi.nlm.nih.gov/pubmed/24413150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.186
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