Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53: TARGETING WARBURG EFFECT TO FIGHT CANCER

Unique sensitivity of tumor cells to the inhibition of glycolysis is a good target for anticancer therapy. Here, we demonstrate that the pharmacologically activated tumor suppressor p53 mediates the inhibition of glycolytic enzymes in cancer cells in vitro and in vivo. We showed that p53 binds to th...

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Detalhes bibliográficos
Main Authors: Zawacka-Pankau, Joanna, Grinkevich, Vera V., Hünten, Sabine, Nikulenkov, Fedor, Gluch, Angela, Li, Hai, Enge, Martin, Kel, Alexander, Selivanova, Galina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308870/
https://ncbi.nlm.nih.gov/pubmed/21862591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240812
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