Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

BACKGROUND AND PURPOSE: Intestinal nutrient transporters may mediate the uptake of drugs. The aim of this study was to investigate whether sertraline interacts with the intestinal proton-coupled amino acid transporter 1 PAT1 (SLC36A1). EXPERIMENTAL APPROACH: In vitro investigations of interactions b...

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Detalhes bibliográficos
Main Authors: Nielsen, C U, Frølund, S, Abdulhadi, S, Sari, H, Langthaler, L, Nøhr, M K, Kall, M A, Brodin, B, Holm, R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949652/
https://ncbi.nlm.nih.gov/pubmed/23962042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12341
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