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Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

We have previously reported that the binding site repertoires of heterodimers formed between retinoid X receptor (RXR) and either retinoic acid receptor (RAR) or thyroid hormone receptor (TR) bound to response elements consisting of directly repeated PuG(G/T)TCA motifs spaced by 1-5 bp [direct repea...

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Published in:EMBO J
Main Authors: Zechel, C, Shen, X Q, Chambon, P, Gronemeyer, H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1994
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394959/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8137825/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06395.x
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