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Neuronal activity regulates extracellular tau in vivo

Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable concentrations. Although its presence there may be relevant to the intercellular spread of tau pathology, the cellular mechanisms regulating tau relea...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yamada, Kaoru, Holth, Jerrah K., Liao, Fan, Stewart, Floy R., Mahan, Thomas E., Jiang, Hong, Cirrito, John R., Patel, Tirth K., Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949564/
https://ncbi.nlm.nih.gov/pubmed/24534188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131685
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