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Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production.

Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism by which this protection is mediated is unclear. Since animal studies strongly suggest that production of endothelium-derived relaxing factor is enhanced by estradiol, we have examined the e...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Arnal, J F, Clamens, S, Pechet, C, Negre-Salvayre, A, Allera, C, Girolami, J P, Salvayre, R, Bayard, F
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1996
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39495/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633024/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4108
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