Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here that PP2A-B55 is the enzyme responsible for dephospho...

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Bibliografiske detaljer
Main Authors: Williams, Byron C, Filter, Joshua J, Blake-Hodek, Kristina A, Wadzinski, Brian E, Fuda, Nicholas J, Shalloway, David, Goldberg, Michael L
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2014
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949306/
https://ncbi.nlm.nih.gov/pubmed/24618897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01695
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