Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons

Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca(2)(+) signals and promotes cytoplasmic generation of reactive oxygen species. These Ca(2)(+) signals, w...

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Hlavní autoři: SanMartín, Carol D., Paula-Lima, Andrea C., García, Alejandra, Barattini, Pablo, Hartel, Steffen, Núñez, Marco T., Hidalgo, Cecilia
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949220/
https://ncbi.nlm.nih.gov/pubmed/24653672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00013
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