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Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca(2)(+) signals and promotes cytoplasmic generation of reactive oxygen species. These Ca(2)(+) signals, w...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949220/ https://ncbi.nlm.nih.gov/pubmed/24653672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00013 |
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