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Ubiquitination Events That Regulate Recombination of Immunoglobulin Loci Gene Segments
Programed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity. Recombinase proteins RAG1 and RAG2, necessary for V(...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949197/ https://ncbi.nlm.nih.gov/pubmed/24653725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00100 |
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