Genetically determined mitochondrial preservation and cardioprotection against myocardial ischemia-reperfusion injury in a consomic rat model

Cardioprotection may be genome dependent. One example is the increased tolerance to cardiac ischemia-reperfusion (IR) in Brown Norway (BN) compared with Dahl salt-sensitive (SS) rats. By narrowing the genetic difference to chromosome 6 only, we found the consomic SS(6BN) to be similarly IR tolerant...

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Autors principals: Nabbi, Raha, Gadicherla, Ashish K., Kersten, Judy R., Stowe, David F., Lazar, Jozef, Riess, Matthias L.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
Matèries:
General Interest
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949105/
https://ncbi.nlm.nih.gov/pubmed/24380873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00118.2013
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