Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) eliminates many epigenetic modifications that characterize differentiated cells. In this study, we tested whether functional differences between chronic obstructive pulmonary disease (COPD) and non-COPD fibroblasts could be reduce...

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Main Authors: Basma, Hesham, Gunji, Yoko, Iwasawa, Shunichiro, Nelson, Amy, Farid, Maha, Ikari, Jun, Liu, Xiangde, Wang, Xingqi, Michalski, Joel, Smith, Lynette, Iqbal, Javeed, Behery, Radwa El, West, William, Yelamanchili, Sowmya, Rennard, Deborah, Holz, Olaf, Mueller, Kai-Christian, Magnussen, Helgo, Rabe, Klaus, Castaldi, Peter J, Rennard, Stephen I.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949084/
https://ncbi.nlm.nih.gov/pubmed/24487392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00255.2013
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