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Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by downregulating NADPH oxidases

Chronic alcohol abuse increases lung oxidative stress and susceptibility to respiratory infections by impairing alveolar macrophage (AM) function. NADPH oxidases (Nox) are major sources of reactive oxygen species in AMs. We hypothesized that treatment with the critical antioxidant glutathione (GSH)...

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Autors principals: Yeligar, Samantha M., Harris, Frank L., Hart, C. Michael, Brown, Lou Ann S.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949056/
https://ncbi.nlm.nih.gov/pubmed/24441868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00159.2013
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