Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD

Basement membrane abnormalities have often been observed in kidney cysts of polycystic kidney disease (PKD) patients and animal models. There is an abnormal deposition of extracellular matrix molecules, including laminin-α(3),β(3),γ(2) (laminin-332), in human autosomal dominant PKD (ADPKD). Knockdow...

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Bibliografiske detaljer
Main Authors: Vijayakumar, Soundarapandian, Dang, Suparna, Marinkovich, M. Peter, Lazarova, Zelmira, Yoder, Bradley, Torres, Vicente E., Wallace, Darren P.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949036/
https://ncbi.nlm.nih.gov/pubmed/24370592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00104.2013
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