Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD

Basement membrane abnormalities have often been observed in kidney cysts of polycystic kidney disease (PKD) patients and animal models. There is an abnormal deposition of extracellular matrix molecules, including laminin-α(3),β(3),γ(2) (laminin-332), in human autosomal dominant PKD (ADPKD). Knockdow...

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Hauptverfasser: Vijayakumar, Soundarapandian, Dang, Suparna, Marinkovich, M. Peter, Lazarova, Zelmira, Yoder, Bradley, Torres, Vicente E., Wallace, Darren P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949036/
https://ncbi.nlm.nih.gov/pubmed/24370592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00104.2013
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