Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

The interleukin-2 (IL-2) promoter consists of several independent T cell receptor (TcR) responsive elements. The induction of promoters dependent on these elements is inhibitable by the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK-506). Calcineurin, a Ca2+/calmodulin-dependent protein p...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Frantz, B, Nordby, E C, Bren, G, Steffan, N, Paya, C V, Kincaid, R L, Tocci, M J, O'Keefe, S J, O'Neill, E A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394885/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8112299/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06329.x
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