Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable genetic mutations in 5–10% of cases, including those in Cu/Zn superoxide dismutase (SOD1). We previously showed that misfolding of SOD1 can be transmitted to endogenous human wild-type SOD1 (HuWtSOD1) in an...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Grad, Leslie I., Yerbury, Justin J., Turner, Bradley J., Guest, William C., Pokrishevsky, Edward, O’Neill, Megan A., Yanai, Anat, Silverman, Judith M., Zeineddine, Rafaa, Corcoran, Lisa, Kumita, Janet R., Luheshi, Leila M., Yousefi, Masoud, Coleman, Bradley M., Hill, Andrew F., Plotkin, Steven S., Mackenzie, Ian R., Cashman, Neil R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2014
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948312/
https://ncbi.nlm.nih.gov/pubmed/24550511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312245111
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