Mutagenesis supports water mediated recognition in the trp repressor-operator system.

High resolution crystallographic analysis of the trp repressor-operator complex indicates that the principal determinants of specificity are water mediated hydrogen bonds between the helix-turn-helix and the identity elements of the operator. One such hydration site involves a conserved G-C base pai...

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Bibliografische gegevens

Gepubliceerd in:	EMBO J
Hoofdauteurs:	Joachimiak, A, Haran, T E, Sigler, P B
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Nature Publishing Group 1994
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394817/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8313881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06270.x
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