Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis

Melioidosis is a severe infection caused by the flagellated bacterium Burkholderia pseudomallei. The nonsense polymorphism TLR5(1174C>T) is associated with improved outcome in Thais with melioidosis. We hypothesized that other TLR5 variants may modulate the host response and determine outcome in...

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Detalhes bibliográficos
Main Authors: Chantratita, Narisara, Tandhavanant, Sarunporn, Myers, Nicolle D., Chierakul, Wirongrong, Robertson, Johanna D., Mahavanakul, Weera, Singhasivanon, Pratap, Emond, Mary J., Peacock, Sharon J., West, T. Eoin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948086/
https://ncbi.nlm.nih.gov/pubmed/24285178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2013.60
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