The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells

The relationship between drug resistance, changes in signaling, and emergence of an invasive phenotype is well appreciated, but the underlying mechanisms are not well understood. Using machine learning analysis applied to the Cancer Cell Line Encyclopedia database, we identified expression of AXL, t...

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Bibliographic Details
Main Authors: Meyer, Aaron S., Miller, Miles A., Gertler, Frank B., Lauffenburger, Douglas A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947921/
https://ncbi.nlm.nih.gov/pubmed/23921085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004155
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