Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4(+)CD45RO(+)CD25(+)CD127(low) regulatory T cells

OBJECTIVE: Despite the high frequency of CD4(+) T cells with a regulatory phenotype (CD25(+)CD127(low)FoxP3(+)) in the joints of patients with rheumatoid arthritis (RA), inflammation persists. One possible explanation is that human Tregs are converted into pro-inflammatory IL-17-producing cells by i...

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Main Authors: Walter, Gina J., Evans, Hayley G., Menon, Bina, Gullick, Nicola J., Kirkham, Bruce W., Cope, Andrew P., Geissmann, Frédéric, Taams, Leonie S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947722/
https://ncbi.nlm.nih.gov/pubmed/23280063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37832
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