Identification of Genetic Variants That Affect Histone Modifications in Human Cells

Histone modifications are important markers of function and chromatin state, yet the DNA sequence elements that direct them to specific genomic locations are poorly understood. Here, we identify hundreds of quantitative trait loci, genome-wide, that affect histone modification or RNA polymerase II (...

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Autors principals: McVicker, Graham, van de Geijn, Bryce, Degner, Jacob F., Cain, Carolyn E., Banovich, Nicholas E., Raj, Anil, Lewellen, Noah, Myrthil, Marsha, Gilad, Yoav, Pritchard, Jonathan K.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947669/
https://ncbi.nlm.nih.gov/pubmed/24136359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1242429
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