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Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)

The discovery of a 2-aryl-3-aroyl indole-based small-molecule inhibitor of tubulin assembly (referred to as OXi8006) inspired the design, synthesis, and biological evaluation of a series of diversely functionalized analogues. In the majority of examples, the pendant 2-aryl ring contained a 3-hydroxy...

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Main Authors: MacDonough, Matthew T., Strecker, Tracy E., Hamel, Ernest, Hall, John J., Chaplin, David J., Lynn Trawick, Mary, Pinney, Kevin G.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947597/
https://ncbi.nlm.nih.gov/pubmed/23993969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.07.028
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