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Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells
Gain-of-function of the neuronal receptor, metabotropic glutamate receptor 1 (Grm1), was sufficient to induce melanocytic transformation in vitro and spontaneous melanoma development in vivo when ectopically expressed in melanocytes. The human form of this receptor, GRM1, has been shown to be ectopi...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947419/ https://ncbi.nlm.nih.gov/pubmed/24330389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12207 |
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