A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor initiating cells

Genomic, transcriptional, and proteomic analyses of brain tumors reveal subtypes that differ in pathway activity, progression, and response to therapy. However, a number of small molecule inhibitors under development vary in strength of subset and pathway-specificity, with molecularly targeted exper...

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Bibliographische Detailangaben
Hauptverfasser: Saito, Norihiko, Fu, Jun, Zheng, Siyuan, Yao, Jun, Wang, Shuzhen, Liu, Diane D., Yuan, Ying, Sulman, Erik P., Lang, Frederick F., Colman, Howard, Verhaak, Roel G., Alfred Yung, W. K., Koul, Dimpy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947402/
https://ncbi.nlm.nih.gov/pubmed/24038660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1528
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