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A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor initiating cells
Genomic, transcriptional, and proteomic analyses of brain tumors reveal subtypes that differ in pathway activity, progression, and response to therapy. However, a number of small molecule inhibitors under development vary in strength of subset and pathway-specificity, with molecularly targeted exper...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947402/ https://ncbi.nlm.nih.gov/pubmed/24038660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1528 |
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