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Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels
Voltage-gated sodium channels (Na(V)s) are central elements of cellular excitation. Notwithstanding advances from recent bacterial Na(V) (BacNa(V)) structures, key questions about gating and ion selectivity remain. Here, we present a closed conformation of Na(V)Ae1p, a pore-only BacNa(V) derived fro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947372/ https://ncbi.nlm.nih.gov/pubmed/24120938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.10.010 |
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