HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer

PURPOSE: Suppression of P53 transcriptional function mediates poor therapeutic response in cancer patients. AURKA and HDM2 are negative regulators of P53. Herein, we examined the role of AURKA in regulating HDM2 and its subsequent effects on P53 apoptotic function in gastric cancer (GC). EXPERIMENTA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sehdev, Vikas, Katsha, Ahmed, Arras, Janet, Peng, Dunfa, Soutto, Mohammed, Ecsedy, Jeffrey, Zaika, Alexander, Belkhiri, Abbes, El-Rifai, Wael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947328/
https://ncbi.nlm.nih.gov/pubmed/24240108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1187
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