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Identification of a mitotic death signature in cancer cell lines
This study examined the molecular mechanism of action of anti-mitotic drugs. The hypothesis was tested that death in mitosis occurs through sustained mitotic arrest with robust Cdk1 signaling causing complete phosphorylation of Mcl-1 and Bcl-xL, and conversely, that mitotic slippage is associated wi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947203/ https://ncbi.nlm.nih.gov/pubmed/24099917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.09.036 |
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