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Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: a promising strategy to overcome drug resistance in cancer

The discovery that survivin, a small anti-apoptotic protein, is involved in chemoresistance, opens a new scenario to overcome the drug resistance in cancer. It was shown that siRNA can efficiently inhibit the expression of survivin in cancer cells. However, the clinical use of siRNA is still hampere...

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Main Authors: Salzano, G, Riehle, R, Navarro, Gemma, Perche, Federico, De Rosa, G, Torchilin, VT
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947185/
https://ncbi.nlm.nih.gov/pubmed/24099916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.09.037
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