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Phase I Design for Completely or Partially Ordered Treatment Schedules

The majority of methods for the design of Phase I trials in oncology are based upon a single course of therapy, yet in actual practice it may be the case that there is more than one treatment schedule for any given dose. Therefore, the probability of observing a dose-limiting toxicity (DLT) may depe...

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Detalhes bibliográficos
Main Authors: Wages, Nolan A., O’Quigley, John, Conaway, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947103/
https://ncbi.nlm.nih.gov/pubmed/24114957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5998
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