Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

The early signals generated following cross-linking of Fas/APO-1, a transmembrane receptor whose engagement by ligand results in apoptosis induction, were investigated in human HuT78 lymphoma cells. Fas/APO-1 cross-linking by mAbs resulted in membrane sphingomyelin hydrolysis and ceramide generation...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Cifone, M G, Roncaioli, P, De Maria, R, Camarda, G, Santoni, A, Ruberti, G, Testi, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8846779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00274.x
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