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Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase

DNA replication in all organisms requires polymerases to synthesize copies of the genome. DNA polymerases are unable to function on a bare template and require a primer. Primases are crucial RNA polymerases that perform the initial de novo synthesis, generating the first 8–10 nucleotides of the prim...

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Bibliografiske detaljer
Main Authors: Vaithiyalingam, Sivaraja, Arnett, Diana R., Aggarwal, Amit, Eichman, Brandt F., Fanning, Ellen, Chazin, Walter J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946992/
https://ncbi.nlm.nih.gov/pubmed/24239947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.11.007
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