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Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase
DNA replication in all organisms requires polymerases to synthesize copies of the genome. DNA polymerases are unable to function on a bare template and require a primer. Primases are crucial RNA polymerases that perform the initial de novo synthesis, generating the first 8–10 nucleotides of the prim...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946992/ https://ncbi.nlm.nih.gov/pubmed/24239947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.11.007 |
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