Prostate cancer derived prostatic acid phosphatase promotes an osteoblastic response in the bone microenvironment

Approximately 90 % of patients who die of prostate cancer (PCa) have bone metastases, often promoting osteoblastic lesions. We observed that 88 % of castration-resistant PCa (CRPC) bone metastases express prostatic acid phosphatase (PAP), a soluble secreted protein expressed by prostate epithelial c...

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Detalhes bibliográficos
Main Authors: Larson, Sandy R., Chin, Jessica, Zhang, Xiaotun, Brown, Lisha G., Coleman, Ilsa M., Lakely, Bryce, Tenniswood, Martin, Corey, Eva, Nelson, Peter S., Vessella, Robert L., Morrissey, Colm
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946934/
https://ncbi.nlm.nih.gov/pubmed/24242705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-013-9625-2
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