Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck

BACKGROUND: RASSF3 suppresses tumour formation through uncertain mechanisms, but it is an important gene of p53-dependent apoptosis. RASSF3 depletion impairs DNA repair after DNA damage, leading to polyploidy. The authors hypothesised that potential functional single-nucleotide polymorphisms (SNPs)...

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Detalhes bibliográficos
Main Authors: Guo, Hongguang, Liu, Hongliang, Wei, Jianhua, Li, Yangkai, Yu, Hongping, Guan, Xiaoxiang, Li-E, Wang, Li, Guojun, Sturgis, Erich M., Wei, Qingyi, Liu, Zhensheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946894/
https://ncbi.nlm.nih.gov/pubmed/24295637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2013.11.009
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