The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.

The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence junction protein catenin. Here we show that overexpression of APC blocks serum-induced cell cycle prog...

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Библиографические подробности
Главные авторы: Baeg, G H, Matsumine, A, Kuroda, T, Bhattacharjee, R N, Miyashiro, I, Toyoshima, K, Akiyama, T
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC394677/
https://ncbi.nlm.nih.gov/pubmed/8521819
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