Circulating Acylcarnitines as Biomarkers of Mitochondrial Dysfunction after Acetaminophen Overdose in Mice and Humans

Acetaminophen (APAP) is a widely used analgesic. However, APAP overdose is hepatotoxic and is the primary cause of acute liver failure in the developed world. The mechanism of APAP-induced liver injury begins with protein binding and involves mitochondrial dysfunction and oxidative stress. Recent ef...

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Detalhes bibliográficos
Main Authors: McGill, Mitchell R., Li, Feng, Sharpe, Matthew R., Williams, C. David, Curry, Steven C., Ma, Xiaochao, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946727/
https://ncbi.nlm.nih.gov/pubmed/23979652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-013-1118-1
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