Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy

Mutations in the connexin 26 gene (GJB2) are the most common genetic cause of deafness, leading to congenital bilateral non-syndromic sensorineural hearing loss. Here we report the generation of a mouse model for a connexin 26 (C×26) mutation, in which cre-Sox10 drives excision of the C×26 gene from...

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Hauptverfasser: Takada, Yohei, Beyer, Lisa A., Swiderski, Donald L., O’Neal, Aubrey L., Prieskorn, Diane M., Shivatzki, Shaked, Avraham, Karen B., Raphael, Yehoash
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946535/
https://ncbi.nlm.nih.gov/pubmed/24333301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2013.11.009
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