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Hsp90-Dependent Assembly of the DBC2/RhoBTB2-Cullin3 E3-Ligase Complex

The expression of the wild-type tumor-suppressor gene DBC2 (Deleted-in-Breast Cancer 2, a.k.a RhoBTB2) is suppressed in many cancers, in addition to breast cancer. In a screen for Cdc37-associated proteins, DBC2 was identified to be a potential client protein of the 90 kDa heat shock protein (Hsp90)...

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Autors principals: Manjarrez, Jacob R., Sun, Liang, Prince, Thomas, Matts, Robert L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946479/
https://ncbi.nlm.nih.gov/pubmed/24608665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090054
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